Inhibitory effect of polyphenols (phenolic acids, lignans, and stilbenes) on cancer by regulating signal transduction pathways: A review

A. Hazafa; M. O. Iqbal; U. Javaid; M. B. K. Tareen; D. Amna; A. Ramzan; S. Piracha; M. Naeem

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Inhibitory effect of polyphenols (phenolic acids, lignans, and stilbenes) on cancer by regulating signal transduction pathways: A review

A. Hazafa ^[1] ; M. O. Iqbal ^[2] ; U. Javaid ^[3] ; M. B. K. Tareen ^[4] ; D. Amna ^[7] ; A. Ramzan ^[5] ; S. Piracha ^[5] ; M. Naeem ^[6]
1. [1] University of Agriculture
  
  University of Agriculture
  
  Pakistán
2. [2] Ocean University of China
  
  Ocean University of China
  
  China
3. [3] Bahauddin Zakariya University
  
  Bahauddin Zakariya University
  
  Pakistán
4. [4] Huazhong Agricultural University
  
  Huazhong Agricultural University
  
  China
5. [5] University of Agriculture Faisalabad
  
  University of Agriculture Faisalabad
  
  Pakistán
6. [6] Hebei Normal University
  
  Hebei Normal University
  
  China
7. [7] Institute of Food Science & Nutrition, Bahauddin Zakariya University, Multan, Pakistan
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Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 24, Nº. 3 (Marzo), 2022, págs. 432-445
Idioma: inglés
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Resumen
- Natural products, especially polyphenols (phenolic acids, lignans, and stilbenes) are suggested to be more potent anticancer drugs because of their no or less adverse effects, excess availability, high accuracy, and secure mode of action. In the present review, potential anticancer mechanisms of action of some polyphenols including phenolic acids, lignans, and stilbenes are discussed based on clinical, epidemiological, in vivo, and in vitro studies. The emerging evidence revealed that phenolic acids, lignans, and stilbenes induced apoptosis in the treatment of breast (MCF-7), colon (Caco-2), lung (SKLU-1), prostate (DU-145 and LNCaP), hepatocellular (hepG-2), and cervical (A-431) cancer cells, cell cycle arrest (S/G2/M/G1-phases) in gastric (MKN-45 and MKN-74), colorectal (HCT-116), bladder (T-24 and 5637), oral (H-400), leukemic (HL-60 and MOLT-4) and colon (Caco-2) cancer cells, and inhibit cell proliferation against the prostate (PC-3), liver (LI-90), breast (T47D and MDA-MB-231), colon (HT-29 and Caco-2), cervical (HTB-35), and MIC-1 cancer cells through caspase-3, MAPK, AMPK, Akt, NF-κB, Wnt, CD95, and SIRT1 pathways. Based on accumulated data, we suggested that polyphenols could be considered as a viable therapeutic option in the treatment of cancer cells in the near future.