Momordica charantia L. improves airway hyperresponsiveness and suppresses inflammation in a murine model of allergic asthma
-
Clara Frota [1] ; Alessa Ribeiro [1] ; Marco Tulio Calil Filho [1] ; Lucas Morel [1] ; Leandra Ramalho [2] ; Jessica Amaral [3] ; Silvia Contini [2] ; Vanessa Fonseca [1] ; Marcos Borges [1] ; Ana Maria Pereira [2] ; Fabio Carmona [1]
-
[1] Universidade de São Paulo
Universidade de São Paulo
Brasil
-
[2] Universidade de Ribeirão Preto
Universidade de Ribeirão Preto
Brasil
-
[3] Universidade Federal de São Carlos
Universidade Federal de São Carlos
Brasil
-
- Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 50, Nº. 2, 2022, págs. 115-123
- Idioma: inglés
- Enlaces
-
Resumen
Objective: To evaluate the effect of a hydroethanolic extract of Momordica charantia L. (“bitter melon”, Cucurbitaceae) leaves (MCHA) on ovalbumin (OVA)-induced asthma model. Balb/c mice were sensitized twice and challenged for 4 alternate days with OVA and then treated with MCHA (500 mg/kg) for 7 consecutive days.
Methods: Control groups received treatment with normal saline or dexamethasone (2 mg/kg) on the same day. We assessed in vivo bronchial hyperresponsiveness and ex-vivo inflammation and mucus production in bronchoalveolar lavage (BAL), lung homogenates, and lung tissue. Results: MCHA significantly improved airway hyperresponsiveness near baseline levels. MCHA administration significantly improved airway and lung inflammation, demonstrated by decreased total and inflammatory cells in BAL, lower levels of IL-5 and IL-13 in lung homogenate, and fewer inflammatory cells in lung tissue. Additionally, MCHA significantly diminished goblet cells in lung tissue.
Conclusions: Administration of a hydroethanolic extract of M. charantia leaves was effective in treating OVA-induced asthma in an animal model.
