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In vivo comparative study of the effects of using the enamel matrix derivative and/or photobiomodulation on the repair of bone defects

    1. [1] Universidade Estadual Paulista

      Universidade Estadual Paulista

      Brasil

    2. [2] Latin American Institute of Dental Research and Teaching, School of Dentistry Ilapeo, Curitiba, Paraná, Brazil; Group for the Research and Study of Laser in Dentistry, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil
    3. [3] Latin American Institute of Dental Research and Teaching, School of Dentistry Ilapeo, Curitiba, Paraná, Brazil
    4. [4] Group for the Research and Study of Laser in Dentistry, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil; Department of Basic Sciences, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil
    5. [5] Group for the Research and Study of Laser in Dentistry, São Paulo State University (UNESP), School of Dentistry, Araçatuba, São Paulo, Brazil; Department of Diagnosis and Surgery, School of Dentistry, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil
  • Localización: Journal of Clinical and Experimental Dentistry, ISSN-e 1989-5488, Vol. 14, Nº. 2 (February), 2022, págs. 114-122
  • Idioma: inglés
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  • Resumen
    • The repair of bone defects has been the subject of many studies that have shown inconclusive results as to what is the best bone substitute.

      Bone defects (Ø 2 mm) were induced on the tibia of seventy-two rats, which were distributed into the following four groups/treatments (n=18 each): Control: no treatment; EMD: enamel matrix derived protein; PBM: photobiomodulation therapy (660 nm, 0,035 W, 60 s); EMD + PBM: EMD and immediate treatment with PBM (660 nm, 0,035 W, 60 s). Six animals from each group were euthanized after 10, 30 and 60 days. Histological and immunohistochemistry analyses (osteocalcin - OCN and tartrate-resistant acid phosphatase - TRAP) were performed with scores for each of the biological events.

      All performed treatments resulted in an increased filling and maturation of bone tissue, being greater in the EMD and EMD + PBM groups in the 30 day period, compared to the Control group. The immunostaining of OCN was greater at 60 days in all treated groups than in the Control over the same period. TRAP immunostaining was higher at 30 days in all treated groups, and lower in groups EMD and PBM after 60 days, compared to the Control over the same period. There was greater immunostaining in the EMD + PBM group after 10 days than in the Control and EMD groups in the same period.

      These results lead to the conclusion that treatments with EMD and PBM, both separate and in association were effective in filling and maturing bone tissue in tibial bone cavities, with greater effectiveness in the period of 30 days in the EMD and EMD + PBM groups.


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