Enfermedad de motoneurona asociada a procesos neoplásicos: una revisión de casos

• Raquel Rocha ^[1] ; Luis Ribeiro ^[1] ; Filipe Correia ^[1] ; Andreia Santos ^[1] ; João Martins ^[1]
  1. [1] Hospital Pedro Hispano

     Hospital Pedro Hispano

     Matosinhos, Portugal

     
• Localización: Galicia Clínica, ISSN 0304-4866, ISSN-e 1989-3922, Vol. 82, Nº. 2 (Abril-Mayo-Junio), 2021, págs. 87-89
• Idioma: español
• Títulos paralelos:
  • Motor neuron disease associated with a neoplastic procesess: a review of cases
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• Resumen

  • Introduction: Association between Motor Neuron Disease (MND) and neoplastic processes is rarely described. It is unclear whether MND occurs as a paraneoplastic syndrome.

    Methods: We retrospectively analysed 35 patients with MND followed in our Hospital from January 2013 to December 2016. Results: A neoplastic process was found in four patients. All of them had definite clinical and electromyographic criteria supporting MND according to standard Awaji criteria.

    Results: Onconeuronal antibodies were positive in two patients (anti-Yo and anti-PNMA2). The types of tumour were variable: two breast cancers, one lung cancer and one thyroid Hürthle cell neoplasm. Discussion: In our cohort, 11.4% of MND patients were diagnosed with a neoplastic process being a rather high frequency of co-occurrence. Treating the neoplastic process may potentially halt or reverse the progression of MND