Relationship of cord blood IgE with maternal, fetal, and environmental factors in the Chinese population

• Mengxue Chen ^[1] ; Yutong Gu ^[1] ; Quanhua Liu ^[1] ; Ruoxu Ji ^[1] ; Jianhua Zhang ^[1] ; Li Hua ^[1]
  1. [1] Shanghai Jiao Tong University

     Shanghai Jiao Tong University

     China

     
• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 49, Nº. 3, 2021, págs. 50-55
• Idioma: inglés
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• Resumen

  • Introduction and objectives: Previous studies reported that history of pregnancy and delivery and family environment might influence cord blood IgE (CB-IgE) levels and development of allergies; however, the association between them is not well-established. This study aimed at investigating the IgE level in the newborn’s umbilical cord blood and its relationship with maternal, fetal, and environmental factors.

    Materials and methods: A total of 989 mothers and their infants were analyzed in this study. Mothers were given a questionnaire that had a series of questions to evaluate demographic information, maternal allergic status, and environmental exposures during pregnancy. Neonatal cord blood samples were taken at the same time for IgE assay.

    Results: By univariate analysis, we found statistically significant correlations between CB-IgE levels and gender (P = 0.000) and delivery mode (P = 0.017). By multivariate analysis, gender was found to have a significant association with CB-IgE levels (P = 0.001). No significant difference was found between CB-IgE levels and antenatal complications, the season of birth, birth weight, gestational age, and household income (P > 0.050).

    Conclusions: In this study, newborn gender was found to be a strong predictor of elevated CB-IgE. The delivery mode was a probable predictor.