Preconception exposure to over-the-counter medications and antibiotics and the risk of childhood asthma in Lebanon: A cross-sectional study

Diana Malaeb; Souheil Hallit; Hala Sacre; Clara Rahme; Bassem Malaeb; Rabih Hallit; Pascale Salameh

Ayuda

Preconception exposure to over-the-counter medications and antibiotics and the risk of childhood asthma in Lebanon: A cross-sectional study

Diana Malaeb ^[1] ; Souheil Hallit ^[2] ; Hala Sacre ^[3] ; Clara Rahme ^[4] ; Bassem Malaeb ^[5] ; Rabih Hallit ^[2] ; Pascale Salameh ^[6]
1. [1] Lebanese International University
  
  Lebanese International University
  
  Líbano
2. [2] Holy Spirit University of Kaslik
  
  Holy Spirit University of Kaslik
  
  Líbano
3. [3] INSPECT-LB: Institut National de Sante Publique, Epidemiologie Clinique et Toxicologie-Liban, Beirut, Lebanon.
4. [4] Research Department, Psychiatric Hospital of the Cross, Jal Eddib, Lebanon.
5. [5] Ain W Zein Medical Village, Lebanon.
6. [6] INSPECT-LB: Institut National de Sante Publique, Epidemiologie Clinique et Toxicologie-Liban, Beirut, Lebanon; Faculty of Pharmacy, Lebanese University, Hadat, Lebanon; Faculty of Medicine, University of Nicosia, Nicosia, Lebanon.
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Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 49, Nº. 2, 2021, págs. 104-112
Idioma: inglés
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- Objective: The aim of this study was to elucidate the relationship between the mother’s use of over-the-counter (OTC) medications during pregnancy and asthma in Lebanese children.
  
  Methods: A cross-sectional study was conducted on Lebanese students in both public and private schools, between January and September 2017, involving 1000 children aged between 4 and 17 years.
  
  Results: The intake of any medication as an independent variable throughout pregnancy reveals that being in a public school compared to a private one (Beta = 0.344) and breastfeeding (Beta = 0.51) were highly associated with lower odds of asthma, while having a positive family of allergic rhinitis (Beta = 2.129) and the intake of any medication during pregnancy (Beta = 7.052) were highly associated with higher odds of asthma.
  
  A second logistic regression, taking as the dependent variable asthmatic versus healthy children and taking each OTC drug as an independent variable, showed that taking paracetamol once per week during pregnancy (Beta = 4.66) and proton pump inhibitors (PPIs) once per month (Beta = 3.498) compared to no intake were significantly correlated with higher probability of asthma.
  
  Conclusion: Our findings showed that the intake of paracetamol, vitamin C, and PPIs during pregnancy is strongly correlated with asthma in the offspring. Since these factors are avoidable, it is necessary to raise awareness among healthcare professionals to reduce the prevalence of asthma in children.