Vitamin D supplementation and severity of atopic dermatitis: Pre-post assessment
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Renata Robl Imoto [1] ; Marjorie Uber [1] ; Kerstin Taniguchi Abagge [1] ; Mônica Nunes Lima [1] ; Nelson Augusto Rosário [1] ; Vânia Oliveira de Carvalho [1]
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[1] Universidade Federal do Paraná
Universidade Federal do Paraná
Brasil
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- Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 49, Nº. 2, 2021, págs. 66-71
- Idioma: inglés
- Enlaces
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Resumen
Background/objectives: There is evidence that vitamin D (VD) supplementation may help in the management of atopic dermatitis (AD). The aim of this study was to assess the influence of VD supplementation on the severity of AD.
Methods: Pre–post interventional study with prospective data collection in patients younger than 14 years. The severity of AD was determined through SCORAD (SCORing Atopic Dermatitis) and classified as mild (SCORAD < 25), moderate (≥25 and <50), and severe (≥50). Skin prick test was performed in all patients. Serum VD levels were classified as sufficient (≥30 ng/mL), insufficient (29 to 21 ng/mL), and deficient (≤20 ng/mL); and those with inadequate levels received oral supplementation of VD for 3 months, and were reassessed after treatment.
Results: A total of 152 patients were included. Patients with sufficient vitamin levels had lower SCORAD values (p = 0.04). Further, 116 patients (76.3%) received VD supplementation and after 3 months, VD levels were significantly higher (35.9 ng/mL) compared to baseline levels (23.7 ng/mL, p < 0.001). At the same time, a reduction in the SCORAD index was observed (19.4 before vs 12.3 after supplementation, p < 0.001). Considering other factors that could influence the decrease in AD severity after VD supplementation, female gender was associated with a worse treatment response (p = 0.02).
Conclusion: Vitamin D supplementation could be an adjuvant in reducing the severity of atopic dermatitis.
