Inhaled corticosteroids may have a protective effect against coronavirus infection

• Alicia Armentia ^[1] ; Sara Fernández Cortés ^[1] ; Angela Moro Simón ^[1] ; Blanca Martín-Armentia ^[1] ; Sara Martín-Armentia ^[2] ; Daniel Ramos Pollo ^[1] ; Juan Claudio Navarro Cañadas ^[1] ; Javier Visa Caño ^[1] ; Álvaro Sanz Rubiales ^[1] ; Joaquín Rodriguez Fra ^[1] ; Sara García Vaquero ^[3] ; Marta Cano Pazos ^[3] ; Jesús Galán de la Calle ^[3] ; Edgardo Raul Lowell ^[3] ; Cristina Crespo Soto ^[1] ; Carmen Sánchez Toledano ^[4] ; Aurora Sacristán Salgado ^[1]
  1. [1] Hospital Universitario Pío del Río Hortega

     Hospital Universitario Pío del Río Hortega

     Valladolid, España

     
  2. [2] Pediatric Service, Delicias Center, Valladolid, Spain.
  3. [3] Medicina de Familia y Comunitaria, ASVAO, Valladolid, Spain.
  4. [4] Coordinadora de la Gerencia de Atención Primaria, Consejería de Sanidad, Madrid, Spain.

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• Localización: Allergologia et immunopathologia: International journal for clinical and investigate allergology and clinical immunology, ISSN-e 1578-1267, ISSN 0301-0546, Vol. 49, Nº. 1, 2021, págs. 113-117
• Idioma: inglés
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  • Background: Spain has been severely affected by the COVID-19 epidemic, with 195,944 persons infected and 20,453 deaths at the time of writing. Older people with respiratory or cardiac conditions are most at risk.

    Objective: The aim was to compare respiratory symptoms in nursing home residents and patients with uncontrolled asthma, who are considered vulnerable to COVID-19.

    Methods: We studied 134 nursing home residents and 139 patients with uncontrolled asthma, groups vulnerable to COVID-19. Demographic characteristics, clinical manifestations, outcomes, key laboratory results, and radiological images were collected from medical records. COVID-19 infection was detected by polymerase chain reaction (PCR).

    Results: Thirteen (9.3%) patients with uncontrolled asthma, all receiving inhaled corticosteroids were infected by COVID-19. Eighty (60%) nursing home residents were infected; only 28, all of whom had received inhaled corticosteroids, had a good prognosis.

    Conclusions: Early treatment with inhaled corticosteroids may be helpful in COVID-19 infection. Persons with an allergy might have some protective mechanisms against coronavirus.