Angina bullosa haemorrhagica: a 14-year multi-institutional retrospective study from Brazil and literature review

• John Lennon Silva-Cunha ^[4] ; Israel Leal Cavalcante ^[5] ; Caio César da Silva Barros ^[1] ; Fernanda Aragão Felix ^[2] ; Luan Borges Venturi ^[6] ; Larissa Santos Amaral Rolim ^[1] ; César Luis Porpino Santos da Silva-Júnior ^[1] ; Emanuel Mendes Sousa ^[3] ; Éricka Janine Dantas da Silveira ^[1] ; Michelle Agostini ^[3] ; Mário José Romanach ^[3] ; Oslei Paes de Almeida ^[7] ; Sílvia Ferreira de Sousa ^[2] ; Bruno Augusto Benevenuto de Andrade ^[3]
  1. [1] Universidade Federal do Rio Grande do Norte

     Universidade Federal do Rio Grande do Norte

     Brasil

     
  2. [2] Universidade Federal de Minas Gerais

     Universidade Federal de Minas Gerais

     Brasil

     
  3. [3] Universidade Federal do Rio de Janeiro

     Universidade Federal do Rio de Janeiro

     Brasil

     
  4. [4] DDS, MSc, PhD student. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil
  5. [5] DDS, MSc, Professor. Department of Dentistry, University of Fortaleza (UNIFOR), Fortaleza, Brazil.
  6. [6] DDS. Hospital Municipal Dr. Cármino Caricchio, São Paulo, Brazil
  7. [7] 0DDS, PhD, Professor. Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 27, Nº. 1 (January), 2022
• Idioma: inglés
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• Resumen

  • Angina bullosa haemorrhagica (ABH) is characterized by the recurrent appearance of blood blisters on the oral mucosa, mainly in adults' soft palate. In general, the blisters rupture spontaneously, lacking the necessity for biopsy. We report the clinical features of 23 ABH cases, emphasizing the clinical behavior and the management of these conditions.

    A retrospective descriptive cross-sectional study was performed. A total of 12,727 clinical records of oral and maxillofacial lesions from four dental services in Brazil were analyzed. Clinical data were collected from the clinical records and evaluated.

    The series comprised 12 males (52.2%) and 11 females (47.8%), with a mean age of 56.8 ± 14.6 years (ranging: 24-82 years) and a 1.1:1 male-to-female ratio. Most of the lesions affected the soft palate (n = 15, 65.2%). Clinically, the lesions presented mainly as an asymptomatic (n = 17, 73.9%) blood-filled blister that ruptured after a few minutes or hours, leaving an erosion. The masticatory trauma was the most frequent triggering event. No patient had coagulation disorders. A biopsy was performed in only four cases (17.4%). Treatment was symptomatic with a favorable outcome.

    ABH is still poorly documented in the literature, and its etiology remains uncertain. ABH mainly affects the soft palate of elderly adults and has a favorable evolution in a few days. The therapeutic approach is often focused only on the relief of symptoms. However, it can share some clinical features with more serious diseases. Therefore, clinicians must recognize these lesions to avoid misdiagnosis.