Tissue Engineering for modeling Epidermolysis Bullosa- Squamous Cell Carcinomas

• A. González Masa ^[1] ; S. Guerrero Aspizua ^[1] ; C.J. Conti ^[2] ; M. García ^[2] ; E. Chacón-Solano ^[3] ; F. Larcher ^[3] ; M. del Río ^[3]
  1. [1] Universidad Carlos III de Madrid

     Universidad Carlos III de Madrid

     Madrid, España

     
  2. [2] Fundación Jiménez Díaz

     Fundación Jiménez Díaz

     Madrid, España

     
  3. [3] Epithelial Biomedicine Division, CIEMAT-CIBERER (U714), Madrid, Spain.

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• Localización: Libro de Actas del XXXVI Congreso Anual de la Sociedad Española de Ingeniería Biomédica / coord. por María Gloria Bueno García, 2018, ISBN 978-84-09-06253-9, págs. 275-278
• Idioma: inglés
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• Resumen

  • Recessive Dystrophic Epidermolysis Bullosa is a rare genodermatosis characterized, among other characteristics, by the presence of cutaneous blisters and the appearance of Squamous Cell Carcinomas that are very aggressive with a rapid lethal outcome; becoming the principal cause of mortality for this disease [1], [2]. Nowadays, there is not treatment neither for its original genetic mutation, or skin blisters nor for their associated tumors, and the short lifetime of these patients with diagnosed cancer, make very difficult to carry out clinical trials [3], [4]. Therefore, in order to evaluate new therapeutic approaches, it is necessary to develop new organotypic models that recapitulates the pathological features of the disease, with a great emphasis on the stroma composition that has been pointed as a key factor for the malignity [2], [5]–[10]. In this work, by use of Tissue Engineering, a Squamous Cell Carcinoma model was generated. Our characterization showed that the bioengineered humanized xenotransplants, resemble the characteristics of the original RDEB-SCC stroma, being a good approach to further understand the pathology and to test antineoplastic drugs directed primarily against the stroma of the tumors.