Antiseptic capacity of 0.05% chlorhexidine digluconate and 0.05% cetylpyridinium chloride. A prospective and microbiological clinical study

• Álvaro Zubizarreta Macho ; Luis Oscar Alonso Ezpeleta ; Gutiérrez-Ortega, Carlos ^[1] ; Juan Ramón Maestre Vera ^[1]
  1. [1] Universidad Alfonso X el Sabio

     Universidad Alfonso X el Sabio

     Villanueva de la Cañada, España

     
• Localización: Científica dental: Revista científica de formación continuada, ISSN 1697-6398, ISSN-e 1697-641X, Vol. 16, Nº. Extra 4 (Versión en inglés de los trabajos ganadores y los segundos clasificados de los premios de la revista), 2019, págs. 4-13
• Idioma: inglés
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• Resumen

  • Introduction: The aim of this study was to evaluate the clinical and microbiological efficacy of an oral rinse (colutory) containing 0.05% chlorhexidine digluconate (CHX) and 0.05% cetylpyridinium chloride (CPC) when compared to another rinse without antiseptic properties, used as adjuvants to oral hygiene methods.

    Material and methods: Using spectrophotometry, a microbiological study was conducted to evaluate the capacity of each rinse to inhibit the formation and adhesion of Streptococcus oralis bacterial biofilm, followed by a randomized and double-blind clinical trial conducted on a sample of 48 patients randomly assigned to either rinse.

    • Oral Rinse A: 0.05% CHX, 0.05% CPC and 0.14% zinc lactate • Oral Rinse B: 0.10% permethol and 0.50% provitamin B5.

    The plaque index (PI), modified gingival index (MGI), and sulcus bleeding index (SBI) were evaluated at one and three months.

    Results: The 0.05% CHX and 0.05% CPCbased mouth rinse showed a high capacity to inhibit formation (P=0.013) and adhesion (P=0.001) of bacterial biofilm. Statistically significant differences in inter-group PI were observed at three months of observation (P<0.001). Differences in the MGI were also observed at one month (P=0.034) and three months of observation (P<0.001); and in the SBI at one month (P=0.004) and at three months of observation (P=0.002).

    Conclusions: The 0.05% CHX and 0.05% CPC-based colutory.