Methodology to improve optical hyperthermia technique application in biological samples using Silica

• O. Casanova Carvajal ^[2] ; Michael Zeinoun ^[2] ; Esther Agudo ^[1] ; Gema de Vargas ^[1] ; Milagros Ramos ^[1] ; J. Serrano Olmedo ^[2]
  1. [1] Universidad Politécnica de Madrid

     Universidad Politécnica de Madrid

     Madrid, España

     
  2. [2] CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Spain
• Localización: Libro de Actas del XXXVI Congreso Anual de la Sociedad Española de Ingeniería Biomédica / coord. por María Gloria Bueno García, 2018, ISBN 978-84-09-06253-9, págs. 213-216
• Idioma: español
• Enlaces
  • Texto Completo Libro (pdf)
• Resumen

  • Silica is considered a highly biocompatible material and an excellent light dispersant agent. Its incorporation in solutions at optimized proportions significantly improved optical hyperthermia technique by decreasing concentrations of gold nanoparticles, radiation power, and irradiation period. In-vitro tests with cancerogenic or non- cancerogenic cell lines were obtained showing a clear difference in the effect of Silica on cancer cells compared to non-carcinogenic cells, Results proved the biocompatibility of Silica lowering the citotoxicity and not harming biological tissues and cells. It was also obtained that optical properties can increase the effect of light to heat transformation in optical hyperthermia, and repair the decrease of GNRs concentration by its light dispersing abilities.