Implications of magnetic resonance resolution in the generation of 3D patient-specific models after myocardial infarction
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[1] Universidad Politécnica de Madrid
Universidad Politécnica de Madrid
Madrid, España
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[2] Advanced Development in Arrhythmia Mechanisms and Therapy Laboratory, Centro Nacional de Investigaciones
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- Localización: Libro de Actas del XXXVI Congreso Anual de la Sociedad Española de Ingeniería Biomédica / coord. por María Gloria Bueno García, 2018, ISBN 978-84-09-06253-9, págs. 11-14
- Idioma: inglés
- Enlaces
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Resumen
Pathophysiological changes after myocardial infarction include myocardial tissue loss and replacement of the extracellular matrix with fibrosis, which generates an intermingling of viable myocytes and collagen that settles a heterogeneous substrate with potentially slow conduction areas leading to potential ventricular arrhythmias. Contrast enhanced cardiac magnetic resonance (ce-CMR), particularly late gadolinium enhancement (LGE-CMR) imaging enables us to differentiate between areas with moderate fibrosis and severe fibrosis, which results in scar characterization as intermedium signal intensity regions (heterogeneous scar) and highly elevated signal intensity regions (dense scar), respectively. LGE-CMR images have been used to generate patient-specific 3D models aiming to reproduce patient-specific substrates after myocardial infarction. Moreover, such models have been aiming to assess the risk of ventricular arrhythmia and sudden cardiac death, although the intrinsic limitations related to imaging resolution and signal intensity thresholds have not been well addressed yet. The results show that 2D LGE-CMR sequences overestimate scar tissue compared with 3D sequences from the same patients. These data represent an important step towards optimization of diagnostic tools and better modeling-based strategies to design new diagnostic and therapeutic approaches after myocardial infarction.
