Use of Endoret® (PRGF®) (Platelet Rich Growth Factor) in the post-extraction socket: a new regenerative approach

• Anitua, Eduardo ^[1]
  1. [1] Fundación Eduardo Anitua
• Localización: Científica dental: Revista científica de formación continuada, ISSN 1697-6398, ISSN-e 1697-641X, Vol. 13, Nº. Extra 4 (Versión en inglés de los trabajos ganadores y los segundos clasificados de los premios de la revista), 2016, págs. 22-27
• Idioma: inglés
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• Resumen

  • Objective. There are numerous techniques on preserving or regenerating the post-extraction socket described in the international literature that employ different materials alone or in combination.

    Materials and methods. A randomized double-blind clinicaltrial was conducted in which post-extraction socketsin mandibular molars were regenerated over a period of 12 weeks. A total of 60 patients were recruited and randomized either to the Endoret® (PRGF®) group (36 patients) or the control group (24 patients).

    Results. Dental CT analysis (cone beam computed tomography: CBCT) at 12 weeks after extraction revealed that the group treated with Endoret® (PRGF®) achieved a socket regeneration volume greater than or equal to 75% in 96.67% of cases, while ony 45.45% of the control group, with statistically significant differences (p=0.005). The percentage of newly formed bone measured by histopathologic examination was 63.08% for Endoret® (PRGF®) compared with 35.56% for the control group. Better epithelialization was also observed at 3, 7 and 15 daysin the experimental group as well as lesser pain.

    Conclusions. The technique evaluated in this clinicaltrial can be considered safe, no negative adverse effects occurred, and it was more effective in improving different aspects of post-extraction socketregeneration (patient quality of life and post-extraction socket regeneration).