Patient iPSC-derived retinal organoids: Observable retinal diseases in-a-dish

Xiao-Hui Zhang ^[2] ; Zi-Bing Jin ^[1]
1. [1] Capital Medical University
  
  Capital Medical University
  
  China
2. [2] Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, China
Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 36, Nº. 7, 2021, págs. 705-710
Idioma: inglés
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Resumen
- Induced pluripotent stem cells (iPSCs), reprogrammed from human somatic cells, hold the capacity to differentiate into most human body cells.
  
  iPSCs can be differentiated into retinal organoids, a three-dimensional structured retina containing various retinal cells. Patient-specific retinal organoids provide a powerful disease model to recapitulate the disease to study the pathogenesis of inherited retinal dystrophies, to screen or discover new drugs, and most importantly to supply an unlimited cell source for retinal regeneration.