Physio‑pathological effects of m6A modification and its potential contribution to melanoma

• Y. Liao ^[1] ; P. Han ^[1] ; Y. Zhang ^[3] ; B. Ni ^[2]
  1. [1] University of Chinese Academy of Sciences

     University of Chinese Academy of Sciences

     China

     
  2. [2] Third Military Medical University

     Third Military Medical University

     China

     
  3. [3] Chongqing International Institute of Immunology, Chongqing 400018, China

  Mostrar afiliaciones +
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 23, Nº. 11, 2021, págs. 2269-2279
• Idioma: inglés
• Enlaces
  • Texto completo (pdf)
• Resumen

  • Methylation of N6-adenosine (m6A) is the most prevalent internal RNA modification and is especially common among the messenger RNAs. These m6A modifications regulate splicing, translocation, stability and translation of RNA through dynamic and reversible interactions with m6A-binding proteins, namely the writers, erasers and readers. RNA methyltrans- ferases catalyze the m6A modifications, while demethylases reverse this methylation. Deregulation of the m6A modification process has been implicated in human carcinogenesis, including melanoma—which carries one of the highest mutant rates.

    In this review, we provide an up-to-date summary of m6A regulation and its biological impacts on normal and cancer cells, with emphasis on the deregulation of m6A modification and m6A regulators in melanoma. In addition, we highlight the prospective potential of exploiting m6A modification in the treatment of melanoma and non-cancer diseases.