COPB2: a transport protein with multifaceted roles in cancer development and progression

• Y. Feng ^[2] ; X. Lei ^[2] ; L. Zhang ^[3] ; H. Wan ^[2] ; H. Pan ; J. Wu ^[4] ; M. Zou ^[1] ; L. Zhu ; Y. Mi
  1. [1] Nanjing University of Chinese Medicine

     Nanjing University of Chinese Medicine

     China

     
  2. [2] Wuxi Medical College, Jiangnan University, Wuxi 214122, Jiangsu Province, China
  3. [3] Department of Urology, Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou 213003, Jiangsu Province, China
  4. [4] Department of Burns and Plastic Surgery, Affiliated Hospital of Jiangnan University, Wuxi 214122, Jiangsu Province, China

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 23, Nº. 11, 2021, págs. 2195-2205
• Idioma: inglés
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• Resumen

  • The Coatomer protein complex subunit beta 2 (COPB2) is involved in the formation of the COPI coatomer protein complex and is responsible for the transport of vesicles between the Golgi apparatus and the endoplasmic reticulum. It plays an impor- tant role in maintaining the integrity of these cellular organelles, as well as in maintaining cell homeostasis. More importantly, COPB2 plays key roles in embryonic development and tumor progression. COPB2 is regarded as a vital oncogene in several cancer types and has been implicated in tumor cell proliferation, survival, invasion, and metastasis. Here, we summarize the current knowledge on the roles of COPB2 in cancer development and progression in the context of the hallmarks of cancer