Use of healthcare REsources and associated COsts in controlled versus uncontrolled carcinoid SYndrome in patients with neuroendocrine tumours:: the RECOSY study

• A. Custodio ^[1] ; P. Jimenez Fonseca ^[2] ; A. Carmona Bayonas ^[5] ; M. J. Gomez ^[5] ; M. I. Del Olmo García ^[3] ; I. Lorenzo ^[6] ; J. Á. Díaz ^[4] ; N. Canal ^[7] ; G. De la Cruz ^[8] ; C. Villabona ^[9]
  1. [1] Hospital Universitario La Paz

     Hospital Universitario La Paz

     Madrid, España

     
  2. [2] Hospital Universitario Central de Asturias

     Hospital Universitario Central de Asturias

     Oviedo, España

     
  3. [3] Hospital Universitario Puerta del Mar

     Hospital Universitario Puerta del Mar

     Cádiz, España

     
  4. [4] Complexo Hospitalario Universitario de Vigo

     Complexo Hospitalario Universitario de Vigo

     Vigo, España

     
  5. [5] Haematology and Medical Oncology Department, Hospital Universitario Morales Meseguer, UMU, IMIB, CP13/00126, PI17/0050 (ISCII & FEDER), Murcia, Spain
  6. [6] Medical Oncology Department, Hospital La Fe, Valencia, Spain
  7. [7] Endocrinology Service, Hospital Clínico de San Carlos, Madrid, Spain
  8. [8] psen, Hospitalet de Llobregat, Barcelona, Spain
  9. [9] Endocrinology Service, Hospital Bellvitge, Hospitalet de Llobregat, Barcelona, Spain

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 23, Nº. 10, 2021, págs. 2046-2056
• Idioma: inglés
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  • Purpose To report healthcare resource use and associated costs in controlled versus uncontrolled carcinoid syndrome (CS) in patients with neuroendocrine tumours.

    Methods A cross-sectional, non-interventional multicentre study was conducted with retrospective data analysis. Resource use was compared between two patient groups: those with controlled CS (> 12 months with no uncontrolled CS episodes) and uncontrolled CS (< 12 months since last uncontrolled episode). Patients were matched for age, sex, and origin and grade of tumour. When no matching patients were available, data from deceased patients were used. Information on healthcare resource use came from review of medical records, patient history and physician reports. Working capacity was assessed using the Work Productivity and Activity Impairment General Health questionnaire.

    Results Twenty-six university hospitals in Spain participated, between July 2017 and April 2018. 137 patients were enrolled;

    104 were analysed (2 groups of 52). Patients with uncontrolled CS had 10 times more emergency department (ED) visits (mean 1.0 vs 0.10 visits; P = 0.0167), were more likely to have a hospital admission (40.4% vs 19.2%; P = 0.0116) and had longer hospital stays (mean 7.87 vs 2.10 days; P = 0.0178) than those with controlled CS. This corresponded to higher annual hospitalisation costs (mean €5511.59 vs €1457.22; P = 0.028) and ED costs (€161.25 vs €14.85; P = 0.0236). The mean annual total healthcare costs were 60.0% higher in patients with uncontrolled than controlled CS (P = NS).

    Conclusion This study quantifies higher health resource use, and higher hospitalisation and ED costs in patients with uncon- trolled CS. Better control of CS may result 3in lower medical costs.