The GALNTL6 Gene rs558129 Polymorphism Is Associated With Power Performance

• Julen Diaz Ramirez ^[1] ; Jesús Álvarez Herms ^[2] ; Arkaitz Castañeda Babarro ; Jon Larruskain ^[3] ; Xabier Ramirez de la Piscina ^[1] ; Oleg V. Borisov ^[4] ; Ekaterina A. Semenova ^[4] ; Elena S. Kostryukova ^[4] ; Nikolay A. Kulemin ^[4] ; Oleg N. Andryushchenko ^[5] ; Andrey K. Larin ^[4] ; Liliya B. Andryushchenko ^[6] ; Edward V. Generozov ^[4] ; Ildus I. Ahmetov ^[6] ; Adrián Odriozola ^[2]
  1. [1] Universidad del País Vasco/Euskal Herriko Unibertsitatea

     Universidad del País Vasco/Euskal Herriko Unibertsitatea

     Leioa, España

     
  2. [2] Department of Sport Sciences, European University of Madrid, Madrid, Spain
  3. [3] Medical Services, Athletic Club, Lezama, Spain
  4. [4] Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency, Moscow, Russia
  5. [5] Department of Physical Education, Financial University Under the Government of the Russian Federation, Moscow, Russia
  6. [6] Department of Physical Education, Plekhanov Russian University of Economics, Moscow, Russia

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• Localización: Journal of strength and conditioning research: the research journal of the NSCA, ISSN 1064-8011, Vol. 34, Nº. 11, 2020, págs. 3031-3036
• Idioma: inglés
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• Resumen

  • The largest genome-wide association study to date in sports genomics showed that endurance athletes were 1.23 times more likely to possess the C allele of the single nucleotide polymorphism rs558129 of N-acetylgalactosaminyltransferase-like 6 gene (GALNTL6), compared with controls. Nevertheless, no further study has investigated GALNTL6 gene in relation to physical performance. Considering that previous research has shown that the same polymorphism can be associated with both endurance and power phenotypes (ACTN3, ACE, and PPARA), we investigated the association between GALNTL6 rs558129 polymorphism and power performance. According to this objective we conducted 2 global studies regarding 2 different communities of athletes in Spain and Russia. The first study involved 85 Caucasian physically active men from the north of Spain to perform a Wingate anaerobic test (WAnT). In the second study we compared allelic frequencies between 173 Russian power athletes (49 strength and 124 speed-strength athletes), 169 endurance athletes, and 201 controls. We found that physically active men with the T allele of GALNTL6 rs558129 had 5.03-6.97% higher power values compared with those with the CC genotype (p < 0.05). Consistent with these findings, we have shown that the T allele was over-represented in power athletes (37.0%) compared with endurance athletes (29.3%; OR = 1.4, p = 0.032) and controls (28.6%; OR = 1.5, p = 0.015). Furthermore, the highest frequency of the T allele was observed in strength athletes (43.9%; odds ratio [OR] = 1.9, p = 0.0067 compared with endurance athletes; OR = 2.0, p = 0.0036 compared with controls). In conclusion, our data suggest that the GALNTL6 rs558129 T allele can be favorable for anaerobic performance and strength athletes. In addition, we propose a new possible functional role of GALNTL6 rs558129, gut microbiome regarding short-chain fatty acid regulation and their anti-inflammatory and resynthesis functions. Nevertheless, further studies are required to understand the mechanisms involved.