Clinicopathologic features of nasopalatine duct cysts: a retrospective study in two Brazilian oral and maxillofacial pathology referral centers

• Israel Leal Cavalcante ^[2] ; Caio César da Silva Barros ^[1] ; John Lennon Silva Cunha ^[3] ; Vitória Maria Sousa Cruz ^[4] ; Gabriele Alves Pedrosa ^[5] ; Amanda de Jesus Santos ^[6] ; Eveline Turatti ^[7] ; Ricardo Luiz Cavalcanti de Albuquerque-Júnior ^[8] ; Roberta Barroso Cavalcante ^[7]
  1. [1] Universidade Federal do Rio Grande do Norte

     Universidade Federal do Rio Grande do Norte

     Brasil

     
  2. [2] DDS, MSc. Oral Pathology Section, Department of Dentistry, University of Fortaleza (UNIFOR), Fortaleza, CE, Brazil
  3. [3] DDS, MSc, PhD student. Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil
  4. [4] DDS, MSc student. Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, SP, Brazil
  5. [5] DDS, University of Fortaleza (UNIFOR), Fortaleza, CE, Brazil
  6. [6] MSc student. Laboratory of Morphology and Experimental Pathology, Institute of Technology and Research, Tiradentes University (UNIT), Aracaju, SE, Brazil
  7. [7] DDS, PhD, Professor. Department of Dentistry, University of Fortaleza (UNIFOR), Fortaleza, CE, Brazil
  8. [8] DDS, PhD, Professor. Laboratory of Morphology and Experimental Pathology, Institute of Technology and Research, Tiradentes University (UNIT), Aracaju, SE, Brazil

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• Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 26, Nº. 5 (September), 2021
• Idioma: inglés
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• Resumen

  • Nasopalatine duct cyst (NDC) is the most common non-odontogenic cyst in the oral cavity. Clinically it is not difficult to suspect these lesions based on clinical and radiographic appearance. However, the histopathological diagnosis may be difficult due to the broad morphological diversity of these lesions. The objective was to analyze the clinicopathological features of NDCs diagnosed in two oral and maxillofacial pathology services in the Brazilian northeast.

    A retrospective clinicopathologic study was performed. A total of 18,121 clinical records of oral lesions from two oral and maxillofacial pathology services in Brazil were analyzed (2000-2020). All NDCs cases were revised and demographic, clinical, radiographic, and histopathological data were collected.

    Among 18,121 diagnoses in the oral pathology services, 45 (0.2%) were NDCs. The series comprises 24 males (53.3%) and 21 females (46.7%), with a mean age of 43.2 years-old. Most lesions were asymptomatic (n = 27, 60%) with an mean size of 2.1 cm. Microscopically, the non-keratinized stratified squamous epithelium was the most common (66.7%). However, in 88.9% of cases, the epithelial lining was varied and composed of two or more types of epithelium. There was no significant association between the type of epithelium and the size of the cysts (p = 0.389). Nerve, blood vessels, hemorrhage, and chronic inflammatory infiltrate were commonly observed. In contrast, there was a low frequency of mucous glands, sebaceous glands, cholesterol clefts, and multinucleated giant cells.

    The clinical, radiographic, and microscopic findings observed in this study are similar to those reported in the literature. Due to the morphological diversity of NDC, it is needed to correlate its histopathological features with the clinical and radiographic findings to establish a correct diagnosis.