Extracellular vesicles derived from mesenchymal stem cells: A platform that can be engineered

• Bo Qin ^[1] ; Qi Zhang ^[2] ; Dan Chen ^[2] ; Hai-yang Yu ^[2] ; Ai-xiang Luo ^[2] ; Liang-peng Suo ^[2] ; Yan Cai ^[3] ; De-yang Cai ^[2] ; Jia Luo ^[2] ; Ju-fang Huang ^[2] ; Kun Xiong ^[2]
  1. [1] Hubei Polytechnic University

     Hubei Polytechnic University

     China

     
  2. [2] Central South University

     Central South University

     China

     
  3. [3] Central South Central South University, Changsha, Hunan, China, Changsha, Hunan, China

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• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 36, Nº. 6, 2021, págs. 615-632
• Idioma: inglés
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  • y. Mesenchymal stem cells play an important role in tissue damage and repair. This role is mainly due to a paracrine mechanism, and extracellular vesicles (EVs) are an important part of the paracrine function.

    EVs play a vital role in many aspects of cell homeostasis, physiology, and pathology, and EVs can be used as clinical biomarkers, vaccines, or drug delivery vehicles. A large number of studies have shown that EVs derived from mesenchymal stem cells (MSC-EVs) play an important role in the treatment of various diseases.

    However, the problems of low production, low retention rate, and poor targeting of MSC-EVs are obstacles to current clinical applications. The engineering transformation of MSC-EVs can make up for those shortcomings, thereby improving treatment efficiency.

    This review summarizes the latest research progress of MSC-EV direct and indirect engineering transformation from the aspects of improving MSC-EV retention rate, yield, targeting, and MSC-EV visualization research, and proposes some feasible MSC-EV engineering methods of transformation.