Exploring Excipients: Enhancing Solubility in Modified Drug Release Systems Using Inexpensive Tableting and Dissolution Methods

• Robert Coyle ^[1] ; Garrett Farrell ^[1] ; Kim McFadden ^[1] ; Patricia Warren ^[1]
  1. [1] Letterkenny Institute of Technology

     Letterkenny Institute of Technology

     Irlanda

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 98, Nº 8, 2021, págs. 2687-2692
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • This practical is aimed at students who have been introduced to the tableting process, drug delivery systems, and dissolution. The student can design and manufacture a tablet investigating the effect of excipients and their role in tablet design and then generate a release profile of the tablet by using a dissolution apparatus, flow-through cell, and UV–vis kinetics. Economical alternatives to the otherwise expensive dies, presses, and dissolution apparatus required to conduct the practical are included so that this can be applied across a range of budgets. With the assumption that most undergraduate laboratories possess a 13 mm KBr die and hydraulic press, a 10 mm die and 6 mm die can cost in excess of €850, while homemade versions can be manufactured for less than €5.