Development of anti-acanthamoebic approaches

• Mohammad Ridwane Mungroo ^[1] ; Tommy Tong ^[1] ; Naveed Ahmed Khan ^[2] ; Tengku Shahrul Anuar ^[3] ; Sutherland K. Maciver ^[4] ; Ruqaiyyah Siddiqui ^[5]
  1. [1] Sunway University

     Sunway University

     Malasia

     
  2. [2] University of Sharjah

     University of Sharjah

     Emiratos Árabes Unidos

     
  3. [3] Universiti Teknologi MARA

     Universiti Teknologi MARA

     Malasia

     
  4. [4] University of Edinburgh

     University of Edinburgh

     Reino Unido

     
  5. [5] American University of Sharjah

     American University of Sharjah

     Emiratos Árabes Unidos

     

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• Localización: International microbiology: official journal of the Spanish Society for Microbiology, ISSN 1139-6709, Vol. 24, Nº. 3, 2021, págs. 363-371
• Idioma: inglés
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• Resumen

  • Acanthamoeba keratitis is a sight-endangering eye infection, and causative organism Acanthamoeba presents a significant concern to public health, given escalation of contact lens wearers. Contemporary therapy is burdensome, necessitating prompt diagnosis and aggressive treatment. None of the contact lens disinfectants (local and international) can eradicate Acanthamoeba effectively. Using a range of compounds targeting cellulose, ion channels, and biochemical pathways, we employed bioassay-guided testing to determine their anti-amoebic effects. The results indicated that acarbose, indaziflam, terbuthylazine, glimepiride, inositol, vildagliptin and repaglinide showed anti-amoebic effects. Compounds showed minimal toxicity on human cells. Therefore, effects of the evaluated compounds after conjugation with nanoparticles should certainly be the subject of future studies and will likely lead to promising leads for potential applications.