A systematic review and meta-analysis on the effectiveness of xenograft to prevent periodontal defects after mandibular third molar extraction
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Jorge Toledano-Serrabona [1] ; Víctor Ruiz-Romero [1] ; Octavi Camps-Font [1] ; Cosme Gay-Escoda [2] ; Mª Ángeles Sánchez-Garcés [1]
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[1] Universitat de Barcelona
Universitat de Barcelona
Barcelona, España
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[2] MD, DDS, MS, PhD, EBOS, OMFS. Chairman and Professor of Oral and Maxillofacial Surgery, Faculty of Medicine and Health Sciences, Dental School, University of Barcelona. Director of the Master’s degree programme in Oral Surgery and Implantology (EFHRE International University/FUCSO). Coordinator/Researcher at IDIBELL (Bellvitge Biomedical Research Institute). Head of the Oral Surgery, Implantology and Maxillofacial Surgery Department at the Teknon Medical Centre, Barcelona, Spain
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- Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 26, Nº. 4, 2021
- Idioma: inglés
- Enlaces
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Resumen
To evaluate the use of guided bone regeneration with xenograft to prevent periodontal defect in the distal aspect of the second molar after the surgical removal of the mandibular third molar.
Three electronic databases (Pubmed, Cochrane Library and Scopus) were searched in April 2020. Randomized clinical trials in non-smokers and healthy patients, with at least six months follow-up, comparing periodontal probing depth, clinical attachment level, alveolar bone level and adverse events were selected by two independent investigators. The risk of bias assessment of the selected studies was evaluated by means of the Cochrane Collaboration’s Tool. Finally, a meta-analysis of the outcomes of interest was performed.
Despite 795 articles were found in the initial search, only three randomized controlled clinical trials were included. Pooled results favoured the use of the xenograft plus collagen membrane over the spontaneous healing in terms of periodontal probing depth gain (MD=2.36; 95% CI 0.69 to 4.03; P=0.005) and clinical attachment level gain (MD=2.52; 95% CI 0.96 to 4.09; P=0.002). No other statistically significant differences were found.
Within the limitations of the present review, the xenograft plus collagen membrane exhibited better periodontal results than spontaneous healing without increasing postoperative complications. However, future well-designed studies with larger samples are required to confirm our results.
