Medication adherence and persistence of psoriatic arthritis patients treated with biological therapy in a specialty pharmacy in Brazil: a prospective observational study
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Ana F. SOUZA ; Michael R. DA SILVA [1] ; Jéssica B. DOS SANTOS ; Alessandra M. ALMEIDA [3] ; Francisco A. ACURCIO [2] ; Juliana ALVARES - TEODORO
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[1] Universidade Federal do Espírito Santo
Universidade Federal do Espírito Santo
Brasil
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[2] Universidade Federal de Minas Gerais
Universidade Federal de Minas Gerais
Brasil
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[3] Faculdade de Ciências Médicas de Minas Gerais
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- Localización: Pharmacy Practice (Granada), ISSN-e 1886-3655, Vol. 19, Nº. 2, 2021
- Idioma: inglés
- Enlaces
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Resumen
- español
Brazil
- English
Background : Pharmaceutical services in Brazil provide access, supply, and rational use of drugs for all population and an effort has been made to improve the quality of these services. Biological drugs are high - cost drugs supplied in Brazil t hat can inhibit disease progression and improve the quality of life of psoriatic arthritis (PsA) patients. However, some patients did not achieve the rapeutic goals.
Objective :
T o evaluate the medication adherence and persistence of PsA patients treated with tumor necrosis factor inhibitors (anti - TNF) drugs and their associated factors.
Methods : A prospective observational study was performed at a single - specialty pharmacy in Belo Horizonte, Brazil. Medication adherenc e, persistence, and clinical outcomes were evaluated at 12 months of follow - up. Medication persistence was historically compared to overall PsA patients treated in Brazil. Associated factors were identified through log - binomial regression.
Results : One hu ndred ninety - seven PsA patients were included in the study, of whom 147 (74.6%) and 142 (72.1%) had medication adherence and persistence, respectively. Patients treated with infliximab presented the highest adherence (90.5%) and persist ence rate (95.2%) in comparison to patients treated with other drugs, except for adalimumab versus infliximab for adherence outcome. All clinical measures significantly improved in patients with medication adherence and persistence. Medication persistence was hi gher for patie nts attended by specialty pharmacy than other PsA patients in Brazil. The associated factors to higher medication adherence w ere lower disease activity by BASDAI, being non - white race, and intravenous drug use. The associated factors to higher medication p ersistence were lower disease activity by Bath Ankylosing Spondylitis Activity Index (BASDAI), intravenous drug use, non - use of corticoids and non - steroidal anti - inflammatory drugs, and comorbidity.
Conclusions : Patients with medication adherence and pers istence had significant improvements in clinical measures, functionality, and quality of life. High medication adherence and persistence to biological therapy were observed and associated with lesser dis ease activity at baseline. Also, medication persisten ce to PsA patients attended in specialty pharmacy was higher than the overall PsA population in Brazil, which indicates the importance of pharmaceutical services to provide health care and promote the effect iveness and safety of biological therapies.
- español
