Resumen de Expression of bone morphogenetic protein 10 in cases with endometrial carcinoma and its clinical signifcance

Y. Hu, L. Yu, D. Xia, F. Liang, C. Cheng, Y. Huang, L. Xiao

• Purpose To investigate the expression of bone morphogenetic protein 10 (BMP-10) in patients with endometrial carcinoma (EC) and its clinical signifcance.

  Methods Totally 143 cancer tissue specimens were sampled from patients with EC and retrospectively analyzed. The immunohistochemical method was adopted for quantifying BMP-10 in EC tissues. Then the patients were assigned to high and low BMP-10 expression groups. The Kaplan–Meier method and log-rank test were adopted to compare the diference of tumor-free survival (TFS) rate and overall survival (OS) rate between the two groups. The COX proportional hazard model was used to analyze independent risk factors afecting the TFS rate and OS rate of patients with EC.

  Results There were 80 patients (55.94%) with low BMP-10 expression and 63 patients with high BMP-10 expression (54.06%). BMP-10 expression was signifcantly correlated with International Federation of Gynecology and Obstetrics (FIGO) stage (P=0.001), myometrial invasion depth (P<0.001), histological grade (P<0.001), and lymph node metastasis (P=0.009). Additionally, TFS rate (P=0.004) and OS rate (P=0.003) in the low BMP-10 expression group were notably lower than those in the high BMP-10 expression group. Multivariate analysis showed that BMP-10 expression (HR: 13.712, 95% CI 1.823–103.158, P=0.011) was an independent risk factor for the TFS of patients with EC. FIGO stage (P=0.001) and BMP-10 expression (HR: 8.655, 95% CI 1.098–68.215, P=0.020) were independent risk factors for the OS of such patients.

  Conclusions BMP-10 can be adopted as a molecular marker for predicting the poor prognosis of patients with EC