Resumen de Prognostic value of 18F‑FDG PET/CT in T‑Lymphoblastic lymphoma before and after hematopoietic stem cell transplantation
N. Sun, W. Qiao, Y. Xing, T. Wang, J. Yang, J. Zhao
Purpose We aimed to evaluate the prognostic value of 18F-FDG PET/CT in patients with relapsed or refractory T-Lymphoblastic lymphoma (T-LBL) undergoing hematopoietic stem cell transplantation (HSCT).
Methods PET/CT was performed in 21 consecutive relapsed or refractory T-LBL patients scheduled for HSCT. All PET/ CT images were assessed using the Deauville criteria, and patients were divided into negative (Deauville≤3) and positive (Deauville>3) groups for comparison. The predictive value of sex, age, Ann Arbor stage, presence of B symptoms, lactate dehydrogenase level, presence of extranodal disease, and PET/CT results before and after HSCT were evaluated.
Results Kaplan–Meier analysis showed that only PET/CT after HSCT (post-PET) was correlated with progression-free survival (PFS) (P=0.030). The Cox regression model also showed that the post-PET-positive group had a higher hazard ratio (HR) than the negative group (HR=3.884 and P=0.049). However, none of the evaluated factors were predictive of overall survival (OS).
Conclusions Pre-PET cannot predict the PFS and OS of patients with T-LBL undergoing HSCT, which means that 18F-FDG PET/CT cannot be used for identifying patients who can beneft from HSCT. Post-PET is not predictive for OS in patients with T-LBL undergoing HSCT. However, post-PET showed strong correlations with PFS, which means that it may be useful for guiding subsequent clinical treatment decisions.
