Ring finger protein 126: A potential biomarker for colorectal cancer

• Chaoqun Huang ^[1] ; Yao Min ^[2] ; Jiuyang Liu ^[3] ; Jing Li ^[2] ; Xiaojun Yang ^[1]
  1. [1] Zhongnan Hospital of Wuhan University

     Zhongnan Hospital of Wuhan University

     China

     
  2. [2] Huazhong University of Science and Technology

     Huazhong University of Science and Technology

     China

     
  3. [3] Clinical Cancer Study Center of Hubei Provence, PR China

  Mostrar afiliaciones +
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 36, Nº. 5, 2021, págs. 559-566
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Background. Colorectal cancer (CRC) is the most common cancer of the digestive system. However, effective therapeutic targets against CRC have not been found yet. Further, the relationship between the expression of ring finger protein 126 (RNF126) and CRC is not clear.

    Material and Methods. The expression level of RNF126 in CRC tissues and cell lines was detected by immunohistochemical staining and western blot.

    Subsequently, endogenous RNF126 expression was inhibited in a CRC cell line using a short hairpin RNA.

    Next, the effect of RNF126 on the properties of CRC cells was studied through different experimental methods.

    Results. We found that the RNF126 protein was mainly localized in the cytoplasm. High RNF126 expression was observed to be an independent risk factor for poor prognosis in CRC patients. In vitro studies showed that RNF126 was able to promote the proliferation, migration, and invasion ability of CRC cells.

    Conclusion. RNF126 acts as an oncogene during CRC development, and may serve as a novel target for CRC treatment.