Urinary N-Terminal Fragment of Titin Reflects Muscle Damage After a Soccer Match in Male Collegiate Soccer Players

Yoko Tanabe; Kazuhiro Shimizu; Emi Kondo; Mikinobu Yasumatsu; Daisuke Nakamura; Hiroyuki Sagayama; Hideyuki Takahashi

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Urinary N-Terminal Fragment of Titin Reflects Muscle Damage After a Soccer Match in Male Collegiate Soccer Players

Yoko Tanabe ^[1] ; Kazuhiro Shimizu ; Emi Kondo ^[3] ; Mikinobu Yasumatsu ^[2] ; Daisuke Nakamura ; Hiroyuki Sagayama ; Hideyuki Takahashi
1. [1] University of Tsukuba
  
  University of Tsukuba
  
  Japón
2. [2] Rikkyo University
  
  Rikkyo University
  
  Japón
3. [3] Sports Medical Center, Japan Institute of Sports Sciences, Tokyo, Japan
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Localización: Journal of strength and conditioning research: the research journal of the NSCA, ISSN 1064-8011, Vol. 35, Nº. 2, 2021, págs. 360-365
Idioma: inglés
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Resumen
- Previous studies have demonstrated that noninvasive urinary N-terminal fragment of titin (U-titin) concentration highly correlates with serum creatine kinase (CK) activity, a classic invasive muscle damage marker. This finding indicates that U-titin could be used to estimate muscle damage. However, these results were achieved using a laboratory-based eccentric exercise model. Therefore, it remains unclear whether U-titin is useful for evaluating muscle damage occurring in field sports events. As a result, we evaluated whether U-titin concentration closely relates to serum CK activity after a soccer match. Seventeen collegiate soccer players (age: 20 +/- 1 year; height: 172 +/- 6 cm; body mass: 65 +/- 5 kg; Yo-Yo intermittent recovery test level 2, 1,135 +/- 196 m) completed a test match (2 halves of 45 minutes separated by 15 minutes of normal half-time). U-titin concentration, serum CK activity, countermovement jump performance, and muscle soreness were assessed 2 hours before the match and 30 minutes, 24 hours, and 48 hours after the match. U-titin concentrations and CK activity similarly increased at 24 hours and returned to the baseline value at 48 hours after the match. Moreover, the percentage of changes in U-titin concentration from baseline after the match significantly and positively correlated with serum CK activity (r = 0.82, p < 0.05). These results suggest that the noninvasive marker U-titin can be used to assess muscle damage conditions in field sports events, such as soccer matches.