Olanzapina y consumo de cocaína en programa de mantenimiento con metadona

• M.A. Landabaso ^[2] ; I. Iraurgi ^[3] ; J.M. Jiménez-Lerma ^[4] ; J. Sanz ^[2] ; R. Calle ^[2] ; A. Larrazabal ^[5] ; A. Aizpuru ^[2] ; M. Gutiérrez ^[1]
  1. [1] Hospital de Cruces

     Hospital de Cruces

     Barakaldo, España

     
  2. [2] Centro de Drogodependencias Barakaldo
  3. [3] MAPS Rekalde. Bilbao
  4. [4] CTT Álava
  5. [5] CSM Rentería. Guipúzcoa

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• Localización: Psiquiatría biológica: Publicación oficial de la Sociedad Española de Psiquiatría Biológica, ISSN 1134-5934, Vol. 8, Nº. 5, 2001, págs. 171-174
• Idioma: español
• Títulos paralelos:
  • Olanzapine and cocaine consumption in a methadone maintenance program
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• Resumen

  • Aims: Treatment with olanzapine was evaluated in 27 patients with repeated cocaine consumption without psychotic symptomatology on a methadone program. Patients and methods: Patients were selected from those who presented recurrent positive cocaine urine analysis over a 6-month period. Patients who consented to inclusion in the study received olanzapine 10 mg/d of for the following 6 months. Results: A very significant decrease in positive cocaine and heroin urine analysis was observed (cocaine 36.73% versus 2.38%; heroin 16.60% versus 4.35%). Likewise, a decrease was found in the mean dose of methadone between the previous 6 months and the 6 months on olanzapin. Five of the 27 patients withdrew from the study. Discussion: Olanzapine administration may favor compliance with the methadone program allowing a reduction in the daily dose of methadone and an important decrease in the consumption of cocaine and/or heroin.