Inducing your neighbors to become like you: cell recruitment in developmental patterning and growth

• Autores: Luis M. Muñoz Nava, Marycruz Flores Flores, Marcos Nahmad
• Localización: International journal of developmental biology, ISSN 0214-6282, Vol. 65, Nº. Extra 4-6, 2021 (Ejemplar dedicado a: Developmental Biology in Ibero-America. Second Part), págs. 357-364
• Idioma: inglés
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• Resumen

  • Cell differentiation, proliferation, and morphogenesis are generally driven by instructive signals that are sent and interpreted by adjacent tissues, a process known as induction. Cell recruitment is a particular case of induction in which differentiated cells produce a signal that drives adjacent cells to differentiate into the same type as the inducers. Once recruited, these new cells may become inducers to continue the recruitment process, closing a feed-forward loop that propagates the growth of a specific cell-type population. So far, little attention has been given to cell recruitment as a developmental mechanism. Here, we review the components of cell recruitment and discuss its contribution to development in three different examples: the Drosophila wing, the vertebrate inner ear, and the mammalian thyroid gland. Finally, we posit some open questions about the role of cell recruitment in organ patterning and growth.