Resumen de SEOM Clinical Guideline of management of soft-tissue sarcoma (2020)

Ana de Juan Ferré, R. Álvarez Álvarez, Antonio Casado Herráez, Josefina Cruz Jurado, Anna Estival González, Javier Martín Broto, Virginia Martínez Marín, A. L. Moreno Vega, Ana Sebio, Claudia M. Valverde

• Soft-tissue sarcomas constitute an uncommon and heterogeneous group of tumors of mesenchymal origin. Diagnosis, treatment, and management should be performed by an expert multidisciplinary team. MRI/CT of the primary tumor and biopsy is mandatory before any treatment. Wide surgical resection with tumor-free tissue margin is the mainstay for localized disease. Radiotherapy is indicated in large, deep, high-grade tumors, or after marginal resection not suitable for re-excision. Perioperative chemotherapy should be discussed for high-risk sarcomas of the extremities and trunk-wall. In the case of oligometastatic disease, patients should be considered for local therapies. First-line treatment with anthracyclines (or in combination with ifosfamide) is the treatment of choice. Other drugs have shown activity in second-line therapy and in specific histological subtypes but options are limited and thus, a clinical trial should always be discussed.