The diagnostic value of miR‑21 combined with CT in patients with liver cancer

• Y. S. Feng ^[2] ; J. M. Zhou ^[3] ; C. H. Sun ^[4] ; J. Zhu ^[5] ; J. Yang ^[6] ; L. Guo ^[1]
  1. [1] Jinan Central Hospital

     Jinan Central Hospital

     China

     
  2. [2] Department of CT Room, The First Afliated Hospital of Nanyang Medical College, Henan 473058, China
  3. [3] Department of Ultrasound Diagnosis, Yantaishan Hospital, Yantai 264000, China
  4. [4] Department of Hepatobiliary Surgery, The Third People’s Hospital of Qingdao, Qingdao 266041, China
  5. [5] Department of Respiratory Medicine, The People’s Hospital of Zhangqiu Area, Jinan 250200, China
  6. [6] Department of Clinical Laboratory, The People’s Hospital of Zhangqiu Area, Jinan 250200, China

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• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 23, Nº. 6, 2021, págs. 1238-1244
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • Purpose To explore the diagnostic value of miR-21 combined with computed tomography (CT) in patients with liver cancer.

    Methods A total of 112 patients in our hospital were confrmed liver cancer by examination, and were collected as cancer group. Another 100 patients with hepatic focal nodular hyperplasia in the same period were collected as control group. The diagnostic value of miR-21 and CT on liver cancer was observed.

    Results The level of miR-21 in cancer group was signifcantly higher than that in control group, the diference was statistically signifcant (p<0.05). The alpha-fetoprotein (AFP) level was tested. It was found that the AFP level in cancer group was signifcantly higher than that in control group (p<0.001). The correlation between AFP and miR-21 levels in liver cancer patients was detected. It turned out that AFP and miR-21 had correlation. According to receiver operating curve (ROC) calculation results, the best cut-of value for miR-21 diagnosis was 4.142. The sensitivity, specifcity and accuracy of diagnosis of miR-21 alone were 64.29%, 87.00% and 75.00%, respectively. The sensitivity, specifcity and accuracy of diagnosis of CT alone were 91.07%, 62.00% and 77.36%, respectively. There were 108 cases of true positive and 80 cases of true negative after combined diagnosis in the two groups. The sensitivity, specifcity and accuracy of combined diagnosis were 96.43%, 80.00% and 88.68%, respectively. Comparing the value of single diagnosis and combined diagnosis, we found that the accuracy, sensitivity and specifcity of combined diagnosis were signifcantly higher than that of single diagnosis (p<0.05).

    Conclusion CT combined with miR-21 has great diagnostic value in liver cancer and may be a potential diagnostic indicator for liver cancer