Role of the parasympathetic nervous system in cancer initiation and progression

• M. Tibensky ^[1] ; B. Mravec ^[1]
  1. [1] Comenius University

     Comenius University

     Eslovaquia

     
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 23, Nº. 4, 2021, págs. 669-681
• Idioma: inglés
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• Resumen

  • The nervous system plays an important role in cancer initiation and progression. Accumulated evidences clearly show that the sympathetic nervous system exerts stimulatory efects on carcinogenesis and cancer growth. However, the role of the parasympathetic nervous system in cancer has been much less elucidated. Whereas retrospective studies in vagotomized patients and experiments employing vagotomized animals indicate the parasympathetic nervous system has an inhibitory efect on cancer, clinical studies in patients with prostate cancer indicate it has stimulatory efects. Therefore, the aim of this paper is a critical evaluation of the available data related to the role of the parasympathetic nervous system in cancer.