Epigenetic alterations in ameloblastomas: a literature review

• Erison-Santana Santos ^[2] ; Carla-Isabelly Rodrigues-Fernandes ^[2] ; Joab-Cabral Cabral ^[2] ; Felipe-Paiva Fonseca ^[1] ; Adriana-Franco-Paes Leme ^[3]
  1. [1] Universidade Federal de Minas Gerais

     Universidade Federal de Minas Gerais

     Brasil

     
  2. [2] Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil
  3. [3] Brazilian Biosciences National Laboratory, The Brazilian Center for Research in Energy and Materials, Campinas, Brazil

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• Localización: Journal of Clinical and Experimental Dentistry, ISSN-e 1989-5488, Vol. 13, Nº. 3 (March), 2021, págs. 295-302
• Idioma: inglés
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• Resumen

  • Ameloblastoma is a locally aggressive tumor, originated from odontogenic epithelium, and affects the jawbones with an elevated recurrence rate. The molecular mechanisms involved with the pathogenesis of this tumor remain undetermined. This review aimed to describe the current data regarding epigenetic alterations in ameloblastoma.

    A systematized electronic search was performed in the English-language literature in three databases, combining the following keywords: ameloblastoma, epigenetic, methylation, noncoding RNA, histone acetylation.

    According to the gathered results of 11 studies in this review, epigenetic alterations could induce the development and progression of ameloblastoma. DNA methylation has been the most assessed mechanism in ameloblastomas.

    Current literature data indicate that epigenetic events can be involved in the etiopathogenesis of ameloblastomas.