Gisela Camolesi, Karem Lopez Ortega, Janaina Braga Medina, Luana Campos, Alejandro Ismael Lorenzo Pouso, Pilar Gándara Vila, Mario Pérez-Sayáns
to systematically review the literature, comparing the healing of osteoradionecrosis (ORN) among the therapeutic alternatives: surgical, pharmacological and combined.
The review was organized according to the PRISMA protocol with regards to the following PICO question: patients with ORN of the jaws (P=Patient); all interventions reported (I = intervention); between all therapies (C=Comparison); healing of lesions (O=outcome).
Surgical treatment was the most common choice (46.3%) followed by pharmacological treatment, exclusively (25.9%) or combined (26.9%). Treatment exclusively by surgical intervention seems to be most effective option, with 51.2% of the lesions healed, OR for healing of 5.7 (CI95% 1.9-16.9, p=0.002). Only 1 case (0.9%) corresponded to low level laser therapy.
It seems clear that early intervention with conservative surgical combined with pharmacological methods improves the prognosis of ORN.
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