The pesticides use and the risk for head and neck cancer: a review of case-control studies

Augusto-César-Leal-da Silva Leonel; Roberta Ferreti Bonan; Mariana-Bitu-Ramos Pinto; Luiz Paulo Kowalski; Danyel Elias da Cruz Perez

Ayuda

The pesticides use and the risk for head and neck cancer: a review of case-control studies

Augusto César Leal da Silva Leonel ^[1] ; Roberta Ferreti Bonan ^[1] ; Mariana Bitu Ramos Pinto ^[1] ; Luiz Paulo Kowalski ^[2] ; Danyel Elias da Cruz Perez ^[1]
1. [1] Universidade Federal de Pernambuco
  
  Universidade Federal de Pernambuco
  
  Brasil
2. [2] A.C. Camargo Cancer Center. Department of Head and Neck Surgery and Otorhinolaryngology, São Paulo, Brazil; Department of Head and Neck Surgery, University of Sao Paulo Medical School, São Paulo, Brazil
Localización: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, ISSN-e 1698-6946, Vol. 26, Nº. 1 (January), 2021
Idioma: inglés
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Resumen
- Tobacco, alcohol consumption, and HPV infection are the most common risk factors for head and neck cancer (HNC). Despite of this, recent evidences are growing on the association between long-term exposure to pesticides and the risk of chronic diseases, including different types of cancer. The present review evaluated in current literature evidence of an association between exposure to pesticides and the occurrence of HNCs.
  
  A literature search of the case-control studies was conducted in the PubMed, Web of science and Cochrane databases. Methodological quality of each study was rated with the Scottish Intercollegiate Guidelines Network (SIGN 50) checklist.
  
  One thousand and thirty-five studies were identified and twelve met all criteria and, therefore, considered for quality assessment and data extraction. According to SIGN 50 criteria, six studies received an overall high-quality. All the studies considered of high quality found a positive association between exposure to pesticides and different HNC sites, including larynx, pharynx and nasal cavity. In addition, the increased risk was associated with the frequency of exposure.
  
  Finally, improving pesticide users' awareness of their risks and proper handling, as well as adopting protective measures such as the use of personal protective equipment, appear to be effective in reducing human health damage.