Resumen de A 28-Day Carbohydrate-Restricted Diet Improves Markers of Cardiovascular Disease in Professional Firefighters
Hunter S. Waldman, JohnEric W. Smith, John G. Lamberth, Brent J. Fountain, Richard J. Bloomer, Matthew B. Butawan, Matthew J. McAllister
This study compared the effects of a 4-week, nonketogenic, carbohydrate-restricted (<25% of calories) diet (CRD) on markers of inflammation and oxidative stress in professional firefighters (FF). Subjects (n = 15) reported to the laboratory for 2 sessions (i.e., baseline and post-CRD) where blood was drawn from an antecubital vein after a 10-hour overnight fast. Dependent variables measured at baseline and post-CRD included adiponectin, insulin, human growth hormone, cortisol, C-reactive protein, albumin, lipids, glucose, amylase, creatine kinase, malondialdehyde (MDA), advance oxidation protein products (AOPP), total nitrate + nitrite, and soluble intracellular adhesion molecule-1. Compared with baseline, the CRD resulted in dramatic improvements to subjects' cardiometabolic profiles, including decreases in AOPP (51.3 +/- 27.3 vs. 32.9 +/- 7.9 ng[middle dot]ml-1), MDA (1.6 +/- 0.6 vs. 1.1 +/- 0.5 [micro]mol[middle dot]L-1), and triglycerides (84.4 +/- 34.4 vs. 64.2 +/- 14.4 mg[middle dot]dl-1), respectively. In addition, the CRD increased total cholesterol (151.5 +/- 23.0 vs. 167.7 +/- 38.2 mg[middle dot]dl-1) and high-density lipoprotein cholesterol (46.3 +/- 12.7 vs. 50.6 +/- 15.5 mg[middle dot]dl-1), but no differences were found with low-density lipoprotein cholesterol. Overall, our results show a 4-week CRD can favorably improve some markers of cardiovascular health in male FF
