Elevated IL-10 concentrations in serum and saliva from patients with oral lichen planus

• Autores: Hongxia Dan, Wenzhao Liu, Jiaqi Wang, Zhiyong Wang, Runqing Lu, Qianming Chen, Xin Zeng, Yu Zhou
• Localización: Quintessence International, ISSN-e 0033-6572, Vol. 42, Nº. 2, 2011, págs. 157-163
• Idioma: inglés
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• Resumen

  • Objective: IL-10 is a cytokine that plays a complex role in the control of immune responses. A case-control study was conducted to investigate the expression pattern of IL-10 in both serum and the whole unstimulated saliva from ethnic Chinese patients with oral lichen planus.

    Method and Materials: Seventy-nine Chinese patients with oral lichen planus were recruited for this study, and 41 healthy volunteers served as a control group. The levels of IL-10 and IFN-g in the serum and saliva were detected using enzyme-linked immunosorbent assay (ELISA). The IFN-g/IL-10 ratio was calculated by direct counting.

    Results: The results demonstrated an expression profile of high IL-10 level and low IFN-g level and IFN-g/IL-10 ratio in both serum and saliva from oral lichen planus patients, compared to the controls. Saliva levels of IL-10 and IFN-g were positively correlated to their serum partners. No significant difference was found among subtypes of oral lichen planus.

    Conclusion: Elevation of IL-10 level might be involved in the pathogenesis of oral lichen planus, and saliva might be a substitute for serum to reflect the disease-related cytokine production in oral lichen planus patients.