The influence of chlorhexidine on the antibacterial effects of MTA
- Autores: Sven-Georg Mittag, Christof Eißner, Lutz Zabel, Karl Thomas Wrbas, Andrej M. Kielbassa
- Localización: Quintessence International, ISSN-e 0033-6572, Vol. 43, Nº. 10, 2012, págs. 901-906
- Idioma: inglés
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Resumen
Objective: To investigate the influence of chlorhexidine in different concentrations when mixed with mineral trioxide aggregate gray (MTA-G) or white (MTA-W). The antibacterial effect on Enterococcus faecalis was used as the primary parameter.
Method and Materials: Similar to the agar diffusion test, Mueller-Hinton agar plates were inoculated with E faecalis (ATCC 19433), and 14 groups (n = 21) were prepared. The specimens consisted of MTA-W and MTA-G, and these were enriched with chlorhexidine concentrations of 0.1%, 0.2%, 0.5%, 1.0%, 1.5%, and 2.0%. Pure MTA-W and MTA-G (each combined with distilled water) were used as controls. After incubation periods of 24 and 48 hours, the inhibiting areolae were measured.
Results: Pure MTA-W, in contrast to pure MTA-G, had no bactericidal effects. With increasing chlorhexidine concentrations of up to 1.5%, a linear increase in bactericidal activity was observed. In contrast, MTA-G showed only a low self-bactericidal influence, and the antibacterial effects with increasing chlorhexidine concentrations were significantly lower than those of MTA-W (P < .001).
Conclusion: When mixed with distilled water, pure MTA-G revealed a low bactericidal effect against E faecalis. The use of chlorhexidine with MTA mixtures leads to an antibacterial effect against E faecalis, and within the first 48 hours, this effect is significantly higher in combination with MTA-W when compared with MTA-G.
