Analysis in the generation of reactive oxygen species through the interaction between the secondary radiation of the compound system (cisplatin and silica nanoparticle) and intracellular water

• G. López-Laurrabaquio ^[1] ; H.S. Cruz-Galindo ^[1] ; M. Moranchely y Rodríguez ^[4] ; J.M. Montejano Carrizales ^[2] ; J.N. Domínguez Kondo ^[3] ; M.P. Cruces Martínez ^[1]
  1. [1] Instituto Nacional de Investigaciones Nucleares

     Instituto Nacional de Investigaciones Nucleares

     México

     
  2. [2] Universidad Autónoma de San Luis Potosí

     Universidad Autónoma de San Luis Potosí

     México

     
  3. [3] Benemérita Universidad Autónoma de Puebla

     Benemérita Universidad Autónoma de Puebla

     México

     
  4. [4] Escuela Superior de Física y Matemáticas y Posgrado, IPN, Ciudad de México, México

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• Localización: Revista Mexicana de Física, ISSN-e 0035-001X, Vol. 66, Nº. 6, 2020, págs. 797-802
• Idioma: inglés
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• Resumen

  • Through computer simulations of Monte Carlo (TOPAS-nBio code), the generation of reactive oxygen species will be analyzed when applying external radiation with electrons which energy is 5 keV to the physical system: composite system and intracellular water. This study of the generation of reactive species was focused exclusively on the interaction between secondary radiation from the composite system and intracellular water. This secondary radiation originates from the platinum atom and oxygens (from the composite system) to be the greater influence relative to platinum, which mainly consists of electrons called Auger. In this work, only the influence of these ionizing electrons in intracellular water is considered, leading to the generation of reactive oxygen species. Furthermore, the interaction between the nanoparticle surface and cisplatin was not taken into account.