Cell-permeable small molecule probes for site-specific labeling of proteins

• Autores: Dawn S. Y. Yeo, Rajavel Srinivasan, Mahesh Uttamchandani
• Localización: Chemical communications, ISSN 1359-7345, Nº. 23, 2003, págs. 2870-2871
• Idioma: inglés
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• Resumen

  • We have successfully synthesized a number of small molecule probes designed for site-specific labeling of N-terminal cysteine-containing proteins expressed in live cells. Their utility for site-specific, covalent modifications of proteins was successfully demonstrated with purified proteins in vitro, and with live bacterial cells in vivo