The C-terminal ester of membrane anchored peptide ion channels affects anion transport

• Autores: Egan Harder, Natasha Djedovic, Riccardo Ferdani
• Localización: Chemical communications, ISSN 1359-7345, Nº. 23, 2003, págs. 2862-2863
• Idioma: inglés
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• Resumen

  • Five heptapeptide derivatives, [CH3(CH2)17]2NCOCH2OCH2CO-Gly-Gly-Gly-Pro-Gly-Gly-Gly-OR, in which R = ethyl, 2-propyl, heptyl, benzyl, and cyclohexylmethyl, were found to transport chloride anion through a phospholipid bilayer to varying extents dependent on the identity of R. It was concluded that the R group is a membrane anchor for the synthetic chloride channels