Protective efficacy of Allium jesdianum on liver parameters, inflammatory cytokines, oxidative injury and apoptotic changes in mercuric chloride-induced hepatotoxicity in rats
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Cyrus Jalili ; Navid Golshani [1] ; Yadollah Bahrami [1] ; Shiva Roshankhah ; Mohammad Reza Salahshoor
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[1] Kermanshah University of Medical Sciences
Kermanshah University of Medical Sciences
Irán
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- Localización: European Journal of anatomy, ISSN-e 1136-4890, Vol. 24, Nº. 5, 2020, págs. 381-389
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Mercuric chloride (MC) is a chemical compound made from a combination of mercury and chlorine causing intracellular oxidative stress generation. Allium jesdianum (AJ), as a member of the Liliace-ae family, has various pharmacological and strong antioxidant properties. This study aimed to evalu-ate the probable therapeutic effects of AJ against hepatocytes degeneration, inflammation, apoptotic changes and oxidative injuries induced by MC ad-ministration. Sixty-four rats were randomly divided in eight groups (n = 8) including groups of control, MC (50 mg/kg), AJ (500, 1000, 2000 μg/ml), and MC+AJ. They were intraperitoneally and orally ad-ministrated for one week. Nitrite oxide, lipid peroxi-dation (LP) levels, and Ferric Reducing Ability ofPlasma (FRAP) assays were conducted to evalu-ate the intracellular antioxidant index.
