Despite the advances in pituitary surgery, radiotherapy, and medical treatment of Cushing’s disease (CD), bilateral adrenalectomy (BLA) still holds a place in the management of this condition, particularly in cases refractory to other therapeutic modalities, or as an emergency measure in patients with severe manifestations of hypercortisolemia. BLA offers immediate control of the cortisol excess but Nelson’s syndrome (NS) is a potential complication with various adverse sequelae.
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