Resumen de The Epidemiology of Pituitary Adenomas
Adrian F. Daly, Albert Beckers
Pituitary adenoma form via a process that is thought to be derived from the clonal expansion of single abnormal cells owing to somatic genetic mutations or chromosomal abnormalities.1,2 In a minority of cases (approximately 5%), familial or heritable diseases often related to known germline genetic mutations are associated with pituitary adenoma formation; these include familial isolated pituitary adenomas (FIPA), multiple endocrine neoplasia types 1 and 4 and X-linked acrogigantism, among others.3 At the tissue level, the occurrence of molecular genetic abnormalities leading to pituitary tumorigenesis is probably a constant process that is addressed by repair or apoptotic pathways, like in other tissues. Pituitary adenomas, when they occur, can be discovered by specific investigation of suggestive signs and symptoms owing to either hormonal dysregulation, or tumor expansion, such as compression by the adenoma of
