PA2.26 antigen (T1a/podoplanin): a small mucin-like transmembrane glycoprotein associated with cell migration and cancer

• Autores: Francisco Gómez Scholl, Carlos Gamallo Amat, Ester Martín Villar, Miguel Quintanilla Avila
• Localización: Revista de oncología: Publicación oficial de la Federación de Sociedades Españolas de Oncología y del Instituto Nacional de Cancerología de México, ISSN 1575-3018, Vol. 5, Nº. 9, 2003, págs. 491-499
• Idioma: inglés
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• Resumen

  • PA2.26 antigen was originally identified as a small mucin-type glycoprotein induced during chemical carcinogenesis on mouse skin. Cloning and sequencing of the murine and human PA2.26 cDNAs revealed that the sequence was identical to other reported proteins termed T1a (a marker for alveolar type I epithelial cells) and podoplanin (a glycoprotein expressed in glomerular podocytes). In this review, we summarise the current knowledge on the biology of PA2.26 (T1a/podoplanin). Although the physiological function of this protein is not well established as yet, several characteristics make this molecule unique among mucin-like glycoproteins. For example, PA2.26 (T1a/podoplanin) appears to play an important role in morphogenesis during development, and it is a marker for the lymphatic endothelium. In cancer, PA2.26 is induced in tumours derived from squamous epithelia, and is associated with cell migration and malignant progression. These findings are discussed in the context of cancer-associated membrane mucins in which PA2.26 antigen, together with a newly-discovered small mucin called dysadherin, form a special group. PA2.26 antigen was originally identified as a small mucin-type glycoprotein induced during chemical carcinogenesis on mouse skin. Cloning and sequencing of the murine and human PA2.26 cDNAs revealed that the sequence was identical to other reported proteins termed T1a (a marker for alveolar type I epithelial cells) and podoplanin (a glycoprotein expressed in glomerular podocytes). In this review, we summarise the current knowledge on the biology of PA2.26 (T1a/podoplanin). Although the physiological function of this protein is not well established as yet, several characteristics make this molecule unique among mucin-like glycoproteins. For example, PA2.26 (T1a/podoplanin) appears to play an important role in morphogenesis during development, and it is a marker for the lymphatic endothelium. In cancer, PA2.26 is induced in tumours derived from squamous epithelia, and is associated with cell migration and malignant progression. These findings are discussed in the context of cancer-associated membrane mucins in which PA2.26 antigen, together with a newly-discovered small mucin called dysadherin, form a special group.