A paradigm shift in the role of NSAIDs in COVID-19: new pathological mechanisms and potential treatment targets

• Autores: Petre Cristian Ilie, Simina Stefanescu, Nicola Veronese
• Localización: Atena Journal of Public Health, ISSN-e 2695-5911, Volumen 2, 2020
• Idioma: inglés
• Títulos paralelos:
  • Un cambio de paradigma en el papel de los AINE en COVID-19: Nuevos mecanismos patológicos y posibles objetivos de tratamiento
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• Resumen

  • Objectives: The pathogeny of SARS-COV2 infection is currently not well defined. In this paper, we present a new perspective of how the SARS-CoV2 infection can lead to severe cases and potential pathways of preventing such cases.

    Methods: In the first part, we describe the role of cyclooxigenase 2 and in the second part, we describe the role of hypoxia inducible factor (HIF).

    Findings: We hypothesize that cyclooxigenase 2 and hypoxia inducible factor with subsequent inflammation and hypoxia can up-regulate each other in a vicious circle of feed-forward that can ultimately lead to “cytokine storm”.

    Conclusions: Breaking this cycle early potentially will have beneficial effects either by improving oxygenation (oxygen being given earlier in the course of the treatment) or by inhibiting COX-2. We also believe, that the use of COX-2 inhibitors early in the course of the disease can improve the outcome and clinical trial are urgently needed.