Neutrophil function is impaired in paediatric patients with malignancy and may be a useful clinical marker

• J. Reiné ^[1] ; K. Cooper ^[2] ; A. Sewell ^[2] ; J. Lyall ^[2] ; C. Thorbinson ^[2] ; E. Hincks ^[2] ; D. M. Ferreira ^[1] ; B. Pizer ^[2] ; B. Morton ^[1]
  1. [1] Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK
  2. [2] Department of Paediatric Oncology, Alder Hey Children’s Hospital, Liverpool, UK
• Localización: Clinical & translational oncology, ISSN 1699-048X, Vol. 22, Nº. 11, 2020, págs. 2121-2125
• Idioma: inglés
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• Resumen

  • PurposePatients treated with cytotoxic chemotherapy are at risk of neutropenia, neutropenic fever and neutropenic sepsis. We hypothesised that pre-existing neutrophil function dysfunction may increase susceptibility to neutropenic fever in pae-diatric patients receiving cytotoxic chemotherapy.MethodsProspective cohort study recruited patients at Alder Hey Children’s NHS Foundation Trust, United Kingdom. We measured neutrophil phagocytic function using a validated flow cytometric whole blood phagocytosis assay in paediatric patients (n = 16) with oncological disease before and after chemotherapy in a prospective cohort study. We recruited healthy children as a control comparator (n = 10).Results We found significantly decreased phagocytic function in oncology patients compared to healthy participants. In five patients who developed neutropenic fever, we observed increased pre-dose neutrophil respiratory burst.ConclusionWith further validation, measurement of neutrophil function could potentially be used to personalise appropriate prophylactic antimicrobial administration for patients receiving cytotoxic chemotherapy.