Unification of the preparation of methotrexate, cytarabine and hydrocortisone intrathecal in a single solution

• Autores: Elena López Montero, A. Mosquera Torre, Manuel Tourís Lores, Beatriz Bernárdez Ferrán, Irene Zarra Ferro
• Localización: European journal of clinical pharmacy: atención farmacéutica, ISSN 2385-409X, Vol. 22, Nº. 2, 2020, págs. 88-90
• Idioma: inglés
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• Resumen

  • In our unit, the solutions of the three drugs administrated intrathecally, methotrexate, cytarabine and hydrocortisone, were prepared separately and differently depending on if it will be administrated for pediatric or adult population. With the aim of unifying the preparations and because the administration of these agents could be greatly facilitated if all three agents were combined in a single solution, we evaluated some pharmaceutical aspects such as pH and osmolality of combined preparations and the separated preparations. It was concluded that the preparation of a single solution had better characteristics of osmolality and pH for intrathecal administration than the separated preparations. © 2020 Rasgo Editorial S.A.. All rights reserved.